Computational Microscopy

The Wadduwage lab is working on novel computational microscopy solutions that can measure biological systems at their most information rich form with minimum redundancy. Through close collaboration with experimental biologists, the lab designs and builds instruments and algorithms to carefully optimize the information flow through optics, electronics and computations. The end result is an efficiency gain, a currency that can be converted to faster measurements, higher throughput, or sometimes novel experiments. 

 

Fluorescence image of a large population of cells undergoing DNA damage repair, acquired using a home-built high-throughput 3D image cytometer. Wadduwage Laboratory

 

Figure 1 - A fluorescence image of a large population of cells undergoing DNA damage repair, acquired using a home-built high-throughput 3D image cytometer. The instrument can image around a million cells in 3D at sub-micron resolution in less than half an hour.

 

A sampling of current projects includes, computational 3D imaging cytometry, high-throughput two-photon deep tissue imaging, compressive hyperspectral imaging, and multiplexed super-resolution imaging.